Spatiotemporal Modelling of CAR-T Cell Therapy in Solid Tumours: Mechanisms of Antigen Escape and Immunosuppression

CAR-T cell therapy has shown substantial efficacy in haematological malignancies, but its application to solid tumours remains limited by poor effector-cell infiltration, functional exhaustion, antigenic heterogeneity, and an immunosuppressive microenvironment. In this study, we develop a new spatio...

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Detalles Bibliográficos

Autor principal:	Maxim Polyakov
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2026-04-01
Colección:	Computation
Materias:	mathematical modelling computational oncology CAR-T therapy computational algorithms reaction–diffusion system partial differential equations
Acceso en línea:	https://www.mdpi.com/2079-3197/14/4/87
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