IRES-driven expression of the capsid protein of the Venezuelan equine encephalitis virus TC-83 vaccine strain increases its attenuation and safety.

The live-attenuated TC-83 strain is the only licensed veterinary vaccine available to protect equids against Venezuelan equine encephalitis virus (VEEV) and to protect humans indirectly by preventing equine amplification. However, TC-83 is reactogenic due to its reliance on only two attenuating poin...

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Hlavní autoři:	Mathilde Guerbois, Eugenia Volkova, Naomi L Forrester, Shannan L Rossi, Ilya Frolov, Scott C Weaver
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2013-01-01
Edice:	PLoS Neglected Tropical Diseases
On-line přístup:	http://europepmc.org/articles/PMC3649961?pdf=render
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