EPA, not DHA, prevents fibrosis in pressure overload-induced heart failure: potential role of free fatty acid receptor 4

Heart failure with preserved ejection fraction (HFpEF) is half of all HF, but standard HF therapies are ineffective. Diastolic dysfunction, often secondary to interstitial fibrosis, is common in HFpEF. Previously, we found that supra-physiologic levels of ω3-PUFAs produced by 12 weeks of ω3-dietary...

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Detalhes bibliográficos

Principais autores:	Julie A. Eclov, Qingwen Qian, Rebecca Redetzke, Quanhai Chen, Steven C. Wu, Chastity L. Healy, Steven B. Ortmeier, Erin Harmon, Gregory C. Shearer, Timothy D. O'Connell
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2015-12-01
coleção:	Journal of Lipid Research
Assuntos:	eicosapentaenoic acid docosahexaenoic acid fibroblast transverse aortic constriction omega-3 polyunsaturated fatty acids
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0022227520309494
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