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SB431542, a Selective Inhibitor of the TGF-β Type I Receptor, Enhances Doxorubicin Antitumor Activity via p63 Activation in Mutant p53 Breast Cancer Cells

Background: TP53 gene mutations are common in breast cancer and are linked to chemoresistance. p63, a p53 family member, can induce apoptosis independently of p53, representing a potential therapeutic target in TP53-mutant tumors. This study evaluated the synergistic effects of SB...

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Principais autores: Yu-Ling Kou, Yu-Jie Liu, Tzu-Chi Hsu, Kuan-Yo Wu, Sih-Tong Chen, Jing-Yan Chen, Kuan-Yu Lin, Hsiao-Hsuan Wang, Yi-Ting Cheng, Chia-Chi Chen, Bi-He Cai
Format: Artigo
Sprog:Inglês
Udgivet: IMR Press 2025-12-01
Serier:Frontiers in Bioscience-Landmark
Fag:
sb431542
doxorubicin
p63
tumor suppressor protein p53
mutation
breast cancer
drug interactions
Online adgang:https://www.imrpress.com/journal/FBL/30/12/10.31083/FBL45389
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