Deletion of microRNA-183-96-182 Cluster in Lymphocytes Suppresses Anti-DsDNA Autoantibody Production and IgG Deposition in the Kidneys in C57BL/6-Faslpr/lpr Mice

Dysregulated miRNAs have been implicated in the pathogenesis of systemic lupus erythematosus (SLE). Our previous study reported a substantial increase in three miRNAs located at the miR-183-96-182 cluster (miR-183C) in several autoimmune lupus-prone mice, including MRL/lpr and C57BL/6-lpr (B6/lpr)....

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Detalhes bibliográficos

Principais autores:	Zhuang Wang, Bettina Heid, Ran Lu, Mohit Sachdeva, Michael R. Edwards, JingJing Ren, Thomas E. Cecere, Deena Khan, Taschua Jeboda, David G. Kirsch, Christopher M. Reilly, Rujuan Dai, S. Ansar Ahmed
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-07-01
coleção:	Frontiers in Genetics
Assuntos:	epigenetics miR-183-96-182 cluster autoantibody inflammatory cytokine systemic lupus erythematosus murine model
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fgene.2022.840060/full
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