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mRNP granule proteins Fmrp and Dcp1a differentially regulate mRNP complexes to contribute to control of muscle stem cell quiescence and activation

Abstract Background During skeletal muscle regeneration, satellite stem cells use distinct pathways to repair damaged myofibers or to self-renew by returning to quiescence. Cellular/mitotic quiescence employs mechanisms that promote a poised or primed state, including altered RNA turnover and transl...

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Uloženo v:
Hlavní autoři: Nainita Roy, Swetha Sundar, Malini Pillai, Farah Patell-Socha, Sravya Ganesh, Ajoy Aloysius, Mohammed Rumman, Hardik Gala, Simon M. Hughes, Peter S. Zammit, Jyotsna Dhawan
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2021-07-01
Edice:Skeletal Muscle
Témata:
Quiescence
mRNP granule
Translational control
mRNA decay
Skeletal muscle
Myoblast
On-line přístup:https://doi.org/10.1186/s13395-021-00270-9
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