Evaluating Controlled Human Malaria Infection in Kenyan Adults with Varying Degrees of Prior Exposure to Plasmodium falciparum using sporozoites administered by intramuscular injection

Background: Controlled human malaria infection (CHMI) studies are a vital tool to accelerate vaccine and drug development. As CHMI trials are performed in a controlled environment, they allow unprecedented, detailed evaluation of parasite growth dynamics (PGD) and immunological responses. However, C...

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Hauptverfasser:	Susanne Helena Hodgson, Elizabeth A Juma, Amina eSalim, Charles eMagiri, Domtila eKimani, Daniel eNjenga, Alfred eMuia, Andrew O Cole, Caroline eOgwang, Ken eAwuondo, Brett eLowe, Marianne eMuene, Peter F Billingsley, Eric eJames, Anusha eGunasekera, B Kim. Lee Sim, Patricia eNjuguna, Thomas W Rampling, Adam eRichman, Yonas eAbebe, Gathoni eKamuyu, Michelle eMuthui, B Kim Lee Sim, Sean eElias, Sassy eMolyneux, Stephen eGerry, Alex eMacharia, Thomas N Williams, Peter C Bull, Adrian VS Hill, Faith H Osier, Simon J Draper, Philip eBejon, Stephen L Hoffman, Bernhards eOgutu, Kevin eMarsh
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2014-12-01
Schriftenreihe:	Frontiers in Microbiology
Schlagworte:	Immunity Malaria challenge falciparum CHMI
Online-Zugang:	http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00686/full
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