Clinical assessment of gepotidacin (GSK2140944) as a victim and perpetrator of drug–drug interactions via CYP3A metabolism and transporters

Abstract Gepotidacin is a novel triazaacenaphthylene antibiotic in phase III development. Based on nonclinical in vitro characterization of gepotidacin metabolism, two phase I studies were conducted in healthy participants to investigate clinical drug–drug interactions (DDIs). We assessed gepotidaci...

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Hlavní autoři:	Aline Barth, Caroline R. Perry, Shaila Shabbir, Maciej J. Zamek‐Gliszczynski, Sebin Thomas, Etienne F. Dumont, Darin B. Brimhall, Dung Nguyen, Meenakshi Srinivasan, Brandon Swift
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2023-04-01
Edice:	Clinical and Translational Science
On-line přístup:	https://doi.org/10.1111/cts.13477
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