Intracranial inflammation and meningeal fibrosis are associated with perivascular changes, altered CSF tracer dynamics, and cognitive decline in a rat model of communicating hydrocephalus

Abstract Background Normal pressure hydrocephalus (NPH), a chronic communicating hydrocephalus characterized by ventriculomegaly and progressive cognitive decline, is increasingly prevalent in today’s rapidly expanding aging population. Although cerebrospinal fluid (CSF) diversion ameliorates sympto...

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Autors principals:	Chih-Ling Wang, Guo-Fang Tseng, Sheng-Tzung Tsai, Li-Jin Chen
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2026-03-01
Col·lecció:	Fluids and Barriers of the CNS
Matèries:	α‑Synuclein Aquaporin 4 Meningeal lymphatics Normal pressure hydrocephalus Perivascular changes CSF clearance
Accés en línia:	https://doi.org/10.1186/s12987-026-00787-5
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