Manipulation of the unfolded protein response: A pharmacological strategy against coronavirus infection.

Coronavirus infection induces the unfolded protein response (UPR), a cellular signalling pathway composed of three branches, triggered by unfolded proteins in the endoplasmic reticulum (ER) due to high ER load. We have used RNA sequencing and ribosome profiling to investigate holistically the transc...

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Autors principals:	Liliana Echavarría-Consuegra, Georgia M Cook, Idoia Busnadiego, Charlotte Lefèvre, Sarah Keep, Katherine Brown, Nicole Doyle, Giulia Dowgier, Krzysztof Franaszek, Nathan A Moore, Stuart G Siddell, Erica Bickerton, Benjamin G Hale, Andrew E Firth, Ian Brierley, Nerea Irigoyen
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2021-06-01
Col·lecció:	PLoS Pathogens
Accés en línia:	https://doi.org/10.1371/journal.ppat.1009644
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