Complement-Coagulation Cross-talk: Factor H-mediated regulation of the Complement Classical Pathway activation by fibrin clots

The classical pathway of the complement system is activated by the binding of C1q in the C1 complex to the target activator, including immune complexes. Factor H is regarded as the key downregulatory protein of the complement alternative pathway. However, both C1q and factor H bind to target surface...

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Hauptverfasser:	Yu-Hoi Kang, Praveen M. Varghese, Ahmad Al Aiyan, Kirsten Pondman, Uday Kishore, Robert B. Sim
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2024-06-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	complement coagulation classical pathway C1q factor H regulation
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1368852/full
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