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GATA6 coordinates cross-talk between BMP10 and oxidative stress axis in pulmonary arterial hypertension

Abstract Pulmonary arterial hypertension (PAH) is a life-threatening condition characterized by a progressive increase in pulmonary vascular resistance leading to right ventricular failure and often death. Here we report that deficiency of transcription factor GATA6 is a shared pathological feature...

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Principais autores: Tetsuo Toyama, Tatiana V. Kudryashova, Asako Ichihara, Stefania Lenna, Agnieszka Looney, Yuanjun Shen, Lifeng Jiang, Leyla Teos, Theodore Avolio, Derek Lin, Ulas Kaplan, Grace Marden, Vrinda Dambal, Dmitry Goncharov, Horace Delisser, Robert Lafyatis, Francesca Seta, Elena A. Goncharova, Maria Trojanowska
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2023-04-01
Serier:Scientific Reports
Online adgang:https://doi.org/10.1038/s41598-023-33779-8
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