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ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase

Objective: Several members of the angiopoietin-like (ANGPTL) family of proteins, including ANGPTL3 and ANGPTL8, regulate lipoprotein lipase (LPL) activity. Deficiency in either ANGPTL3 or ANGPTL8 reduces plasma triglyceride levels and increases LPL activity, whereas overexpression of either protein...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Xun Chi, Emily C. Britt, Hannah W. Shows, Alexander J. Hjelmaas, Shwetha K. Shetty, Emily M. Cushing, Wendy Li, Alex Dou, Ren Zhang, Brandon S.J. Davies
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017-10-01
Schriftenreihe:Molecular Metabolism
Schlagworte:
Plasma triglycerides
Lipoprotein metabolism
Lipolysis
Lipase inhibition
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2212877817303307
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