Targeting the NLRP3 inflammasome in kidney disease: molecular mechanisms, pathogenic roles, and emerging small-molecule therapeutics

Inflammatory responses represent a core pathological process driving the progression of both acute and chronic kidney diseases. As a key effector of the innate immune system, the NLRP3 inflammasome is widely activated in renal resident cellsand infiltrating immune cells, positioning it as a critical...

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Bibliographic Details

Main Authors:	Yanfang Luo, Muyang Long, Xueqin Wu, Liuting Zeng
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2025-11-01
Series:	Frontiers in Immunology
Subjects:	NLRP3 inflammasome kidney disease pathogenesis small-molecule inhibitors pyroptosis therapeutic targeting
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1703560/full
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