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CRISPR/Cas9-Induced Mutagenesis Corroborates the Role of Transportin-SR2 in HIV-1 Nuclear Import

ABSTRACT To infect nondividing cells, HIV-1 needs to cross the nuclear membrane. The importin transportin-SR2 (TRN-SR2 or transportin-3) has been proposed to mediate HIV-1 nuclear import, but the detailed mechanism remains unresolved. The direct interaction of TRN-SR2 with HIV-1 integrase (IN) has b...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Julie Janssens, Jolien Blokken, Yulia Lampi, Flore De Wit, Irena Zurnic Bonisch, Ivan Nombela, Paulien Van de Velde, Barbara Van Remoortel, Rik Gijsbers, Frauke Christ, Zeger Debyser
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2021-10-01
Schriftenreihe:Microbiology Spectrum
Schlagworte:
CRISPR-Cas9
HIV-1 nuclear import
transportin-SR2
human immunodeficiency virus
Online-Zugang:https://journals.asm.org/doi/10.1128/Spectrum.01336-21
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