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Safety and efficacy of low-dose intravenous arsenic trioxide in systemic lupus erythematosus: an open-label phase IIa trial (Lupsenic)

Abstract Background Lupus animal model has shown that arsenic trioxide (ATO), a treatment of acute promyelocytic leukaemia, could be effective in SLE. This is the first clinical study to determine the safety and efficacy of a short course of intravenous ATO in patients with active SLE. Methods This...

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Principais autores: Mohamed Hamidou, Antoine Néel, Joel Poupon, Zahir Amoura, Mikael Ebbo, Jean Sibilia, Jean-Francois Viallard, Benjamin Gaborit, Christelle Volteau, Jean Benoit Hardouin, Eric Hachulla, François Rieger
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2021-03-01
Serier:Arthritis Research & Therapy
Fag:
Systemic lupus erythematosus
Autoimmune diseases
Treatment
Arsenic trioxide
Phase II clinical trial
Online adgang:https://doi.org/10.1186/s13075-021-02454-6
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