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YAP/TAZ initiate and maintain Schwann cell myelination

Nuclear exclusion of the transcriptional regulators and potent oncoproteins, YAP/TAZ, is considered necessary for adult tissue homeostasis. Here we show that nuclear YAP/TAZ are essential regulators of peripheral nerve development and myelin maintenance. To proliferate, developing Schwann cells (SCs...

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Main Authors: Matthew Grove, Hyukmin Kim, Maryline Santerre, Alexander J Krupka, Seung Baek Han, Jinbin Zhai, Jennifer Y Cho, Raehee Park, Michele Harris, Seonhee Kim, Bassel E Sawaya, Shin H Kang, Mary F Barbe, Seo-Hee Cho, Michel A Lemay, Young-Jin Son
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications Ltd 2017-01-01
Series:eLife
Subjects:
Egr2
TEAD
Taz
demyelination
Schwann cells
Online Access:https://elifesciences.org/articles/20982
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