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Humanized monoacylglycerol acyltransferase 2 mice on a high-fat diet exhibit impaired liver detoxification during metabolic dysfunction-associated steatotic liver disease.

Obesity significantly increases the risk of hyperlipidemia, type 2 diabetes, and liver disease. This study examined humanized monoacylglycerol acyltransferase 2 mice (HuMgat2) and their response to a high fat diet (HFD) while investigating hepatocyte dysfunction during obesity development. HuMgat2 m...

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Detalhes bibliográficos
Principais autores: J Jose Corbalan, Pranavi Jagadeesan, Joseph T Nickels
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2025-01-01
coleção:PLoS ONE
Acesso em linha:https://doi.org/10.1371/journal.pone.0334213
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