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Development of a BM7G(TKO/hCD46/hCD55/hTHBD/hEPCR) donor pig with endogenous promoter-driven transgenes for xenotransplantation

IntroductionXenotransplantation holds promise for addressing the organ shortage crisis. Multi-genetic modification of pigs, such as knockout of three carbohydrate antigen-related genes and expression of immunoprotective proteins, can significantly improve xenograft survival. However, existing multi-...

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Principais autores: Cong Xia, Meng Lian, Bingxiu Ma, Hongliang Yu, Renquan Zhang, Lijia Wen, Xueliang Wang, Yu Zhao, Zhen Ouyang, Yinghua Ye, Xiner Feng, Han Wu, Liangxue Lai
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-06-01
Serier:Frontiers in Immunology
Fag:
coagulation response
complement regulation
endogenous promoter
multi-genetic modification
xenotransplantation
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1827497/full
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