Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via histone acetylation

Myocardial infarction (MI) is accompanied by severe energy deprivation and extensive epigenetic changes. However, how energy metabolism and chromatin modifications are interlinked during MI and heart repair has been poorly explored. Here, we examined the effect of different carbon sources that are i...

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Detalhes bibliográficos

Principais autores:	Ienglam Lei, Shuo Tian, Wenbin Gao, Liu Liu, Yijing Guo, Paul Tang, Eugene Chen, Zhong Wang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2021-12-01
coleção:	eLife
Assuntos:	histone acetylation acetyl-CoA reactive oxygen species ischemia reperfusion interplay between metabolism epigenetics
Acesso em linha:	https://elifesciences.org/articles/60311
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