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Design, Synthesis and Biological Evaluation of Novel Coumarin-Based Hydroxamate Derivatives as Histone Deacetylase (Hdac) Inhibitors with Antitumor Activities

A series of novel coumarin-based hydroxamate derivatives were designed and synthesized as histone deacetylase inhibitors (HDACis). Selective compounds showed a potent HDAC inhibition with nM IC<sub>50</sub> values, with the best compound (<b>10e</b>) being nearly 90 times more active than vorinostat...

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Principais autores: Feifei Yang, Na Zhao, Jiali Song, Kongkai Zhu, Cheng-shi Jiang, Peipei Shan, Hua Zhang
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2019-07-01
סדרה:Molecules
נושאים:
coumarin
hydroxamate
HDAC inhibitors
antitumor growth
structure–activity relationship
גישה מקוונת:https://www.mdpi.com/1420-3049/24/14/2569
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