Germline ATM Mutations Detected by Somatic DNA Sequencing in Lethal Prostate Cancer

Background: Germline mutations in the ataxia telangiectasia mutated (ATM) gene occur in 0.5–1% of the overall population and are associated with tumour predisposition. The clinical and pathological features of ATM-mutated prostate cancer (PC) are poorly defined but have been associated with lethal P...

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主要な著者:	Rafael Grochot, Suzanne Carreira, Susana Miranda, Ines Figueiredo, Claudia Bertan, Jan Rekowski, Wei Yuan, Ana Ferreira, Ruth Riisnaes, Antje Neeb, Bora Gurel, Maria de Los Dolores Fenor de la Maza, Christina Guo, Juliet Carmichael, Daniel Westaby, Joaquin Mateo, Adam Sharp, Terri P. McVeigh, Johann De Bono
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2023-06-01
シリーズ:	European Urology Open Science
主題:	Prostate cancer ATM DNA damage response Synthetic lethality PARP inhibition ATR inhibition
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2666168323001933
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