The tumour microenvironment of the upper and lower gastrointestinal tract differentially influences dendritic cell maturation

Abstract Background Only 10–30% of oesophageal and rectal adenocarcinoma patients treated with neoadjuvant chemoradiotherapy have a complete pathological response. Inflammatory and angiogenic mediators in the tumour microenvironment (TME) may enable evasion of anti-tumour immune responses. Methods T...

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Detalhes bibliográficos

Principais autores:	Maria E. Morrissey, Róisín Byrne, Celina Nulty, Niamh H. McCabe, Niamh Lynam-Lennon, Clare T. Butler, Susan Kennedy, Dermot O’Toole, John Larkin, Paul McCormick, Brian Mehigan, Mary-Clare Cathcart, Joanne Lysaght, John V. Reynolds, Elizabeth J. Ryan, Margaret R. Dunne, Jacintha O’Sullivan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2020-06-01
coleção:	BMC Cancer
Assuntos:	Gastrointestinal cancer Dendritic cell inhibition Tumour conditioned media Tumour microenvironment Radiotherapy TNF-α
Acesso em linha:	http://link.springer.com/article/10.1186/s12885-020-07012-y
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