HDAC6 promotes inflammation in lupus nephritis mice by regulating transcription factors MAFF and KLF5 in renal fibrosis

Aim This study explored the effect and mechanism of MAFF and HDAC6 on renal fibrosis and inflammation in lupus nephritis (LN).Methods IL-33 treated renal epithelial cells and MRL/lpr mice were respectively used for in vitro and in vivo experiments. The expressions of HDAC6, MAFF, and KLF5 were measu...

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Autori principali: Meihui Deng, Xiao Tan, Xiaojie Peng, Weimin Zheng, Rui Fu, Shanshan Tao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis Group 2024-12-01
Serie:Renal Failure
Soggetti:
Lupus nephritis
renal fibrosis
HDAC6
MAFF
KLF5
MRL/lpr mice
Accesso online:https://www.tandfonline.com/doi/10.1080/0886022X.2024.2415517
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