New Genetic Bomb Trigger: Design, Synthesis, Molecular Dynamics Simulation, and Biological Evaluation of Novel BIBR1532-Related Analogs Targeting Telomerase against Non-Small Cell Lung Cancer

Telomeres serve a critical function in cell replication and proliferation at every stage of the cell cycle. Telomerase is a ribonucleoprotein, responsible for maintaining the telomere length and chromosomal integrity of frequently dividing cells. Although it is silenced in most human somatic cells,...

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Principais autores:	Haytham O. Tawfik, Anwar A. El-Hamaky, Eman A. El-Bastawissy, Kirill A. Shcherbakov, Alexander V. Veselovsky, Yulia A. Gladilina, Dmitry D. Zhdanov, Mervat H. El-Hamamsy
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-04-01
coleção:	Pharmaceuticals
Assuntos:	2-Amino-3-cyanothiophene <b>BIBR1532</b> telomerase enzyme TRAP assay molecular dynamics simulation inhibitors
Acesso em linha:	https://www.mdpi.com/1424-8247/15/4/481
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