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CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth

Summary: The mammalian target of rapamycin complex1 (mTORC1) is a central regulator of metabolism and cell growth by sensing diverse environmental signals, including amino acids. The GATOR2 complex is a key component linking amino acid signals to mTORC1. Here, we identify protein arginine methyltran...

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Príomhchruthaitheoirí: Shasha Yin, Liu Liu, Lauren E. Ball, Yalong Wang, Mark T. Bedford, Stephen A. Duncan, Haizhen Wang, Wenjian Gan
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Elsevier 2023-04-01
Sraith:Cell Reports
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Rochtain ar líne:http://www.sciencedirect.com/science/article/pii/S2211124723003273
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