iPSC-derived NK cells engineered with CD226 effectively control acute myeloid leukemia
Abstract CD226 plays a vital role in NK cell cytotoxicity, interacting with its ligands on tumor targets. Acute myeloid leukemia (AML) cells have developed mechanisms to escape NK cell cytotoxicity, including inducing downregulation of CD226 on NK cells. Induced pluripotent stem cell -derived NK (iP...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
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BMC
2025-07-01
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| Schriftenreihe: | Experimental Hematology & Oncology |
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| Online-Zugang: | https://doi.org/10.1186/s40164-025-00686-9 |
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