Inputs and outputs of poly(ADP-ribosyl)ation: Relevance to oxidative stress
Oxidative stress can cause DNA breaks which induce activation of the DNA nick sensor enzyme poly(ADP-ribose) polymerase-1 (PARP-1), part of the 17 member PARP enzyme family. PARP-1 modifies target proteins by attaching to them several NAD-derived ADP-ribose units forming poly(ADP-ribose) (PAR) polym...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
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Elsevier
2014-01-01
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| Schriftenreihe: | Redox Biology |
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| Online-Zugang: | http://www.sciencedirect.com/science/article/pii/S2213231714000937 |
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