Hippocampus-Based Mitochondrial Respiratory Function Decline Is Responsible for Perioperative Neurocognitive Disorders

Perioperative neurocognitive disorders (PNDs) are a type of cognitive dysfunction occurring with a higher incidence in elderly patients. However, the pathological mechanism of PND and effective treatment remain elusive. We generated a PND mouse model by providing wild-type mice with surgical trauma;...

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Detalhes bibliográficos

Principais autores:	Keqiang He, Juan Zhang, Wei Zhang, Sheng Wang, Dingfeng Li, Xiaolin Ma, Xiaofan Wu, Xiaoqing Chai, Qiang Liu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-02-01
Colecção:	Frontiers in Aging Neuroscience
Assuntos:	perioperative neurocognitive disorders postoperative cognitive dysfunction neuroinflammation mitochondrial respiratory chain complex respiratory function
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnagi.2022.772066/full
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