T-type calcium channel Cav3.2 deficient mice show elevated anxiety, impaired memory and reduced sensitivity to psychostimulants.

The fine-tuning of neuronal excitability relies on a tight control of Ca2+ homeostasis. The low voltage-activated T-type calcium channels (Cav3.1, Cav3.2 and Cav3.3 isoforms) play a critical role in regulating these processes. Despite their wide expression throughout the central nervous system, the...

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Principais autores:	Giuseppe eGangarossa, Sophie eLaffray, Emmanuel eBourinet, Emmanuel eValjent
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2014-03-01
coleção:	Frontiers in Behavioral Neuroscience
Assuntos:	Anxiety drugs of abuse Psychostimulants memory and learning spontaneous behavior T-type Ca2+ channels
Acesso em linha:	http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00092/full
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