Research and optimization of screening strategy for calcium-activated chloride channel modulators guided by electrophysiological characteristics

Abstract Calcium-activated chloride channels (CaCCs) are essential for epithelial secretion, neuronal transmission, and smooth muscle function. Among the Anoctamin family, Anoctamin 1 (ANO1) and Anoctamin 2 (ANO2) are classical CaCCs proteins. ANO1 has been identified as a potential therapeutic targ...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Yanyan Wang, Kai Zheng, Liu Yang, Liying Liu, Haojian Han, Shuang Chen, Zhanning Qu, Kai Qin, Wansheng Zhang, Feng Hao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-02-01
coleção:	Scientific Reports
Assuntos:	CaCCs ANO1 ANO2 Electrophysiological characteristics HTS Screening strategy
Acesso em linha:	https://doi.org/10.1038/s41598-026-39762-3
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!