S-adenosylmethionine metabolism shapes CD8+ T cell functions in colorectal cancer

Abstract Metabolite nutrients within the tumor microenvironment shape both tumor progression and immune cell functionality. It remains elusive how the metabolic interaction between T cells and tumor cells results in different anti-cancer immunotherapeutic responses. Here, we use untargeted metabolom...

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Principais autores:	Xiaohua Yang, Tianzhang Kou, Hongmiao Wang, Ji Zhu, Zheng-Jiang Zhu, Yuping Cai
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2025-05-01
Series:	Cancer & Metabolism
Assuntos:	Metabolite nutrients CD8+ T cell function Microsatellite stable colorectal cancer Metabolomics S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) metabolism
Acceso en liña:	https://doi.org/10.1186/s40170-025-00394-2
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