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Multi-omics approach reveals dysregulated genes during hESCs neuronal differentiation exposure to paracetamol

Summary: Prenatal paracetamol exposure has been associated with neurodevelopmental outcomes in childhood. Pharmacoepigenetic studies show differences in cord blood DNA methylation between unexposed and paracetamol-exposed neonates, however, causality and impact of long-term prenatal paracetamol expo...

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Principais autores: Mari Spildrejorde, Athina Samara, Ankush Sharma, Magnus Leithaug, Martin Falck, Stefania Modafferi, Arvind Y.M. Sundaram, Ganesh Acharya, Hedvig Nordeng, Ragnhild Eskeland, Kristina Gervin, Robert Lyle
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-10-01
Serier:iScience
Fag:
Developmental neuroscience
Neurotoxicology
In vitro toxicology
Stem cells research
Genomics
Transcriptomics
Online adgang:http://www.sciencedirect.com/science/article/pii/S2589004223018321
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