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Impact of Formulation Conditions on Lipid Nanoparticle Characteristics and Functional Delivery of CRISPR RNP for Gene Knock-Out and Correction

The CRISPR-Cas9 system is an emerging therapeutic tool with the potential to correct diverse genetic disorders. However, for gene therapy applications, an efficient delivery vehicle is required, capable of delivering the CRISPR-Cas9 components into the cytosol of the intended target cell population....

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Bibliografiske detaljer
Principais autores: Johanna Walther, Danny Wilbie, Vincent S. J. Tissingh, Mert Öktem, Heleen van der Veen, Bo Lou, Enrico Mastrobattista
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-01-01
Serier:Pharmaceutics
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Online adgang:https://www.mdpi.com/1999-4923/14/1/213
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