Evidence for reduced BRCA2 functional activity in Homo sapiens after divergence from the chimpanzee-human last common ancestor

Summary: We performed a comparative analysis of human and 12 non-human primates to identify sequence variations in known cancer genes. We identified 395 human-specific fixed non-silent substitutions that emerged during evolution of human. Using bioinformatics analyses for functional consequences, we...

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Bibliographic Details

Main Authors:	Jinlong Huang, Yi Zhong, Alvin P. Makohon-Moore, Travis White, Maria Jasin, Mark A. Norell, Ward C. Wheeler, Christine A. Iacobuzio-Donahue
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2022-05-01
Series:	Cell Reports
Subjects:	CP: Cancer
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124722005356
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