Firing activity of locus coeruleus noradrenergic neurons decreases in necdin-deficient mice, an animal model of Prader–Willi syndrome

Abstract Background Prader–Willi syndrome (PWS) is a neurodevelopmental disorder characterized by multiple respiratory, cognitive, endocrine, and behavioral symptoms, such as central apnea, intellectual disabilities, exaggerated stress responses, and temper tantrums. The locus coeruleus noradrenergi...

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Detalhes bibliográficos

Principais autores:	Rui-Ni Wu, Wei-Chen Hung, Ching-Tsuey Chen, Li-Ping Tsai, Wen-Sung Lai, Ming-Yuan Min, Shi-Bing Wong
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2020-07-01
coleção:	Journal of Neurodevelopmental Disorders
Assuntos:	Necdin Prader–Willi syndrome Hypotonia Hypercapnia Locus coeruleus A-type potassium current
Acesso em linha:	http://link.springer.com/article/10.1186/s11689-020-09323-4
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