TORC2 inhibition triggers yeast chromosome fragmentation through misregulated Base Excision Repair of clustered oxidation events

Abstract Combinational therapies provoking cell death are of major interest in oncology. Combining TORC2 kinase inhibition with the radiomimetic drug Zeocin results in a rapid accumulation of double-strand breaks (DSB) in the budding yeast genome. This lethal Yeast Chromosome Shattering (YCS) requir...

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Principais autores:	Kenji Shimada, Cleo V. D. Tarashev, Stephanie Bregenhorn, Christian B. Gerhold, Barbara van Loon, Gregory Roth, Verena Hurst, Josef Jiricny, Stephen B. Helliwell, Susan M. Gasser
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2024-11-01
Series:	Nature Communications
Acceso en liña:	https://doi.org/10.1038/s41467-024-54142-z
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