Population Pharmacokinetics of Temocillin Administered by Continuous Infusion in Patients with Septic Shock Associated with Intra-Abdominal Infection and Ascitic Fluid Effusion

Temocillin is active against Gram-negative bacteria, including many extended-spectrum β-lactamase (ESBL)-producing Enterobacterales. We studied its pharmacokinetics in plasma and ascitic fluid after intravenous administration of a loading dose of 2 g over 30 min, followed by continuous infusion of 6...

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Detalhes bibliográficos

Principais autores:	Perrin Ngougni Pokem, Xavier Wittebole, Christine Collienne, Hector Rodriguez-Villalobos, Paul M. Tulkens, Laure Elens, Françoise Van Bambeke, Pierre-François Laterre
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-07-01
coleção:	Antibiotics
Assuntos:	temocillin intra-abdominal infection ascitic fluid population pharmacokinetics Monte Carlo simulations
Acesso em linha:	https://www.mdpi.com/2079-6382/11/7/898
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