Dehydroandrographolide attenuates Toll-like receptor signaling by dual inhibition of MyD88- and TRIF-dependent pathways

Abstract Toll-like receptors (TLRs) are key mediators of innate immune responses, and their dysregulation contributes to inflammatory diseases. Dehydroandrographolide (DAG), a diterpene lactone from Andrographis paniculata, is known for its anti-inflammatory activity, but its effects on individual b...

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Bibliografiska uppgifter

Huvudupphov:	Ye Eun Lee, Hanbin Ko, Dongwoo Lee, Ha Eun Park, Seo-Yeong Kim, Gyuri Park, Seonah Kim, Younghyun Lee, Hyung-Sun Youn, Gyo Jeong Gu
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Nature Portfolio 2026-04-01
Serie:	Scientific Reports
Ämnen:	Anti-inflammation Dehydroandrographolide MyD88-dependent pathway Toll-like receptor signaling TRIF-dependent pathway
Länkar:	https://doi.org/10.1038/s41598-026-47514-6
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