Refining an acute respiratory distress syndrome animal model supported by extracorporeal membrane oxygenator: incorporating clinically relevant mechanical ventilation strategy upon development

Abstract Background Acute respiratory distress syndrome (ARDS) requiring veno-venous extracorporeal membrane oxygenation (VV-ECMO) is associated with high mortality. One of the primary challenges in translating preclinical findings into effective clinical treatments lies in developing animal models...

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Hauptverfasser:	Keibun Liu, Gabriele Fior, Nchafatso Obonyo, Hideaki Nonaka, Angelo Milani, Gabriella Abbate, Sofia Portatadino, Chiara Palmieri, Shinichi Ijuin, Kei Sato, Silver Heinsar, Sun Kyun Ro, Lucia Gandini, Kota Hoshino, Noriko Sato, Samia Farah, Carmen Ainola, Margaret R. Passmore, Rachana Panduru, Mahe Bouquet, Emily S. Wilson, Kieran Hyslop, Molly-rose McInerney, Cheng Zhang, Caitlin McGrath, Joshua Paech, Jacky Y. Suen, John F. Fraser, Gianluigi Li Bassi
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	SpringerOpen 2026-04-01
Schriftenreihe:	Intensive Care Medicine Experimental
Schlagworte:	Acute respiratory distress syndrome Acute lung injury Extracorporeal membrane oxygenation Lipopolysaccharide Mechanical ventilation Positive end-expiratory pressure
Online-Zugang:	https://doi.org/10.1186/s40635-026-00892-7
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