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Largazole Pharmacokinetics in Rats by LC-MS/MS

A highly sensitive and specific LC-MS/MS method for the quantitation of largazole thiol, the active species of the marine-derived preclinical histone deacetylase inhibitor, largazole (prodrug), was developed and validated. Largazole thiol was extracted with ethyl acetate from human or rat plasma alo...

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Guardat en:
Autors principals: Mingming Yu, Lilibeth A. Salvador, Sherwin K. B. Sy, Yufei Tang, Ravi S. P. Singh, Qi-Yin Chen, Yanxia Liu, Jiyong Hong, Hartmut Derendorf, Hendrik Luesch
Format: Artigo
Idioma:Inglês
Publicat: MDPI AG 2014-03-01
Col·lecció:Marine Drugs
Matèries:
largazole
LC-MS/MS
pharmacokinetics
protein binding
Accés en línia:http://www.mdpi.com/1660-3397/12/3/1623
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