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CYP3A4*1B and CYP3A5*3 SNPs significantly impact the response of Egyptian candidates to high-intensity statin therapy to atorvastatin

Abstract Background A single nucleotide polymorphism (SNP) is a variation in the DNA sequence that results from the alteration of a single nucleotide in the genome. Atorvastatin is used to treat hypercholesterolemia. It belongs to a class of drugs called statins, which lower elevated levels of total...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Mohammed G. Maslub, Nur Aizati Athirah Daud, Mahasen A. Radwan, Abubakar Sha’aban, Arafa G. Ibrahim
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2024-11-01
Schriftenreihe:European Journal of Medical Research
Schlagworte:
Atorvastatin
CYP3A4*1B
CYP3A5*3
Genetic polymorphism
SNPs
Effectiveness
Online-Zugang:https://doi.org/10.1186/s40001-024-02109-7
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