Harnessing tumor acidity: innovative lactic acid-responsive promoter enables precision control of CAR-T cell activity in solid tumors

Background The acidic tumor microenvironment (TME) in solid tumors, driven by abnormal metabolism and lactic acid accumulation, suppresses chimeric antigen receptor-T (CAR-T) cell efficacy while posing safety risks from on-target, off-tumor toxicity (OTOT). This study aims to develop a novel CAR-T t...

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Detalhes bibliográficos

Principais autores:	Xiaoyan Zhang, Chen Zhao, Yangyang Hu, Xiangqing Ding, Qibin Liao, Jianqing Xu, Ying Xue, Cuisong Zhu, Meiqi Feng, Linxia Zhang, Lingyan Zhu, Nairong Zheng, Yunyu Mao, Ai Xia
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMJ Publishing Group 2026-02-01
coleção:	Journal for ImmunoTherapy of Cancer
Acesso em linha:	https://jitc.bmj.com/content/14/2/e013672.full
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