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Bioactivity and Structural Properties of Novel Synthetic Analogues of the Protozoan Toxin Climacostol

Climacostol (5-[(2Z)-non-2-en-1-yl]benzene-1,3-diol) is a resorcinol produced by the protozoan Climacostomum virens for defence against predators. It exerts a potent antimicrobial activity against bacterial and fungal pathogens, inhibits the growth of several human and rodent tumour cells, and is no...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Federico Buonanno, Elisabetta Catalani, Davide Cervia, Francesca Proietti Serafini, Simona Picchietti, Anna Maria Fausto, Simone Giorgi, Gabriele Lupidi, Federico Vittorio Rossi, Enrico Marcantoni, Dezemona Petrelli, Claudio Ortenzi
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2019-01-01
Schriftenreihe:Toxins
Schlagworte:
Climacostomum virens
secondary metabolites
resorcinolic lipids
protists
ciliates
apoptosis
Online-Zugang:http://www.mdpi.com/2072-6651/11/1/42
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