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An In Vitro Analysis of the Effects of Intravenous Lipid Emulsion on Free and Total Local Anaesthetic Concentrations in Human Blood and Plasma

Background. Intravenous lipid emulsion (ILE) is recommended as a “rescue” treatment for local anaesthetic (LA) toxicity. A purported mechanism of action suggests that lipophilic LAs are sequestered into an intravascular “lipid-sink,” thus reducing free drug concentration. There is limited data avail...

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Principais autores: Louise Ann Clark, Jochen Beyer, Andis Graudins
Format: Artigo
Jezik:Inglês
Izdano: Wiley 2014-01-01
Serija:Critical Care Research and Practice
Online dostop:http://dx.doi.org/10.1155/2014/236520
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