Saturation Genome Editing Targeting <i>KRAS</i> Mutations in HCT 116 Colon Carcinoma Cells for Pooled SNV Functional Profiling in Diploid Cancer Model

Evaluating cancer gene mutations is critical for effective therapeutic selection. Although massive parallel sequencing can efficiently detect gene mutations, most are variants of uncertain significance (VUS). Saturation genome editing (SGE) can facilitate VUS analysis by leveraging CRISPR-Cas9 and h...

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Egile Nagusiak:	Taiji Hamada, Seiya Yokoyama, Ryo Nakabayashi, Yoshihiko Suzuki, Shinichi Morishita, Toshiaki Akahane, Kei Matsuo, Ikumi Kitazono, Tatsuhiko Furukawa, Akihide Tanimoto
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	MDPI AG 2026-03-01
Saila:	Current Issues in Molecular Biology
Gaiak:	saturation genome editing variants of uncertain significance <i>KRAS</i> HCT 116 cells colon carcinoma <i>KRAS</i> <sup>G12C</sup> inhibitor
Sarrera elektronikoa:	https://www.mdpi.com/1467-3045/48/4/341
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