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TPP-Thiazole Derivatives Ameliorate Psoriasiform Inflammation by Glycolysis Inhibition

Psoriasis, a chronic inflammatory skin disease, is driven by immune dysregulation and keratinocyte hyperproliferation, with current biologics facing limitations. Emerging evidence points to mitochondrial dysfunction and a pathological shift to aerobic glycolysis as core disease drivers. Here, we rep...

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Autori principali: Xinwei Meng, Ci-An Cheng, Zhirui Zhang, Siying Qu, Anqi Zhang, Yang Zhang, Jinxin Gu, Hanwen Zhang, Keyue Ding, Lei Fu, Mengchen Lu, Daiyun Huang, Yixue Qiao
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2026-03-01
Serie:Molecules
Soggetti:
TPP-thiazole derivatives
psoriasiform inflammation
mitochondria
glycolysis inhibition
immune-metabolic regulation
Accesso online:https://www.mdpi.com/1420-3049/31/6/982
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