miR-1246 enhances chemo-resistance of polyploid giant cancer cells in H1299 cells by targeting GSK3β/β-catenin

Abstract Non-small cell lung cancer (NSCLC) is characterized by a high mortality rate. Chemotherapy has been observed to potentially increase the prevalence of polyploid giant cancer cells (PGCCs), which may play a role in the development of chemo-resistance in NSCLC. The dysregulated expression of...

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Autori principali:	Lili Wang, Zien Yang, Sining Xing, Song Zhao, Mingyue Ouyang, Huiying Yu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Springer 2025-05-01
Serie:	Discover Oncology
Soggetti:	Non-small cell lung cancer Polyploid giant cancer cells miR-1246 GSK3β β-catenin Chemo-resistance
Accesso online:	https://doi.org/10.1007/s12672-025-02756-0
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