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Dual Inhibition of GSK3 and JAK by BIO Suppresses Osteoblast Differentiation and Mineralization of Human Mesenchymal Cells

Glycogen synthase kinase-3 (GSK3) inhibition is a commonly used approach to promote osteogenic differentiation through activation of Wnt signaling. However, 6-bromoindirubin-3′-oxime (BIO), which is commonly used for GSK3 inhibition, also targets JAK/STAT, raising the possibility of dual pathway int...

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Principais autores: Nihal Almuraikhi, Latifa Alkhamees, Sumaiya Tareen, Manikandan Muthurangan
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-03-01
Serier:Current Issues in Molecular Biology
Fag:
GSK3 signaling
JAK/STAT signaling
human bone marrow MSCs
osteoblast differentiation
Online adgang:https://www.mdpi.com/1467-3045/48/3/316
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