Thymidine phosphorylase in nucleotide metabolism: physiological functions and its implications in tumorigenesis and anti-cancer therapy

Thymidine phosphorylase (TYMP), a protein found in both prokaryotic and eukaryotic cells, is encoded by a gene located in the q13 region of chromosome 22. With a relative molecular mass of 55,000, TYMP exists as a homodimer. Recent research has increasingly illuminated the diverse functions of TYMP....

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Autors principals:	Bo Huang, Qihang Yuan, Jiaao Sun, Chao Wang, Dong Yang
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2025-04-01
Col·lecció:	Frontiers in Immunology
Matèries:	nucleotide metabolism thymidine phosphorylase physiological functions tumorigenesis anticancer therapy
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1561560/full
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